Mobilizing the Immune System in the Treatment of Oncologic and Neurodegenerative Diseases
TARGETING THE ANTIGEN-PRESENTING CELLS OF THE IMMUNE SYSTEM TO ENHANCE IMMUNITY AND TRANSPORT ANTI-INFLAMMATORY AND ANTIPROLIFERATIVE AGENTS TO DISEASE SITES
The Antigen-presenting Cells (APCs) are responsible for maintaining the immune system’s balanced and measured response to disease by producing a broad array of signals to mobilize cellular, cytokine, and antibody defenses. Specialized APCs, the circulating monocytes, migrate to disease sites where they are transformed into pro-inflammatory or anti-inflammatory macrophages. While both types of macrophage play vital roles in defense against diseases, excessive production of either type is counter therapeutic. Elevated ratios of pro-inflammatory macrophages contribute to neuroinflammatory diseases such as Alzheimer’s, while elevated ratios of anti-inflammatory macrophages contribute to tumor growth, metastasis, and progression of cancers.
TARGETING THE APCS WITH THE CLR-TARGOSPHERE®
Augustus Bio Target has secured a platform targeting technology, the TargoSphere®, from Rodos Bio Target GmbH in Germany in a collaborative agreement designed to develop novel treatments for neurodegenerative diseases and cancers. The CLR-TargoSphere® is a patented carbohydrate-labeled nanocarrier that recognizes carbohydrate receptor sites on the surface of APCs and delivers encapsulated agents into a pathway that evades intracellular endolysosomal enzymatic degradation. The ability to escape degradation is critical to the successful delivery of unmodified and pharmacologically active agents to diseased sites, and is unique among all competing targeted and non-targeted nanocarriers.
Additionally, the CLR-TargoSphere® has been shown to deliver therapeutic contents across the Blood Brain Barrier, concentrated in perivascular spaces and areas rich in glial cells, with intracellular delivery into astrocytes, the cells intimately associated with Alzheimer’s disease and demyelinating disorders such as Multiple Sclerosis.
- CLR-TargoSphere® encapsulated paclitaxel
- CLR-TargoSphere® encapsulated curcumin
- CLR-TargoSphere® encapsulated gemcitabine
Paclitaxel: a generic apoptotic, antiproliferative, and immune-enhancing agent. In addition to its approved use for multiple oncologic indications, it also inhibits abnormal protein tau hyperphosphorylation in Alzheimer’s disease.
Curcumin: a generic natural curcuminoid antiproliferative and anti-inflammatory agent. It also has anti-amyloidogenic activity and induces degradation of amyloid beta deposits and uptake by macrophages in Alzheimer’s disease.
Gemcitabine: a generic antiproliferative agent approved for multiple oncologic indications, has synergistic antiproliferative activities with paclitaxel and curcumin. A non-targeted combination of gemcitabine and paclitaxel (nab-paclitaxel) was FDA approved in 2013 as a first-line treatment for metastatic pancreatic carcinoma. The CLR-TargoSphere® targeted combination of gemcitabine, paclitaxel, and curcumin is designed to improve clinical outcomes over non-targeted gemcitabine and nab-paclitaxel.
OUR CLINICAL GOALS:
CLR-TargoSphere® encapsulated gemcitabine, paclitaxel, and curcumin have been developed for in-vivo preclinical and clinical trials to:
- COLON CANCER: Restoring Immune Function. We hypothesize that targeted delivery of Curcumin to antigen presenting cells in the immune system can suppress tumor growth for a variety of cancers. This study will examine tumor responses to Curcumin in a colon cancer mouse model when given alone or in combination with an immune Checkpoint Inhibitor. Positive results will lead to Fast-Track FDA applications for human and companion pet animal cancer trials. [More…]
- CHRONIC TRAUMATIC ENCEPHALOPATHY (CTE): CTE is caused by neurodegenerative damage associated with repeated Injuries to the head. It is found in military personnel, as well as adolescents and adults engaged in competitive sports. It is becoming a major global public health concern for which there is no treatment, and ultimately leads to progressive dementia and an untimely death.
We have begun a preclinical study targeting the brain with CLR-TargoSphere® encapsulated Curcumin to take advantage of its multiple anti-inflammatory effects.
Our goal is to show that CLR-TargoSphere® encapsulated Curcumin will be shuttled across the Blood Brain Barrier when targeted to Antigen Presenting Cells (APCs) of the Immune System. We are attempting to prove that APCs can deliver encapsulated curcumin to cells associated with the neurodegenerative changes found in CTE. [More…]
- ALZHEIMER’S DISEASE: Administer the CLR-TargoSphere® encapsulated combination of paclitaxel and curcumin to cross the Blood Brain Barrier for a dual treatment strategy to retard development of tau neurofibrillary tangles and impaired synaptic transmission, and to decrease formation and aggregation of amyloid deposits.The Goal: Delay progression of cognitive impairments in early and mid-stage Alzheimer’s disease.
- METASTATIC PANCREATIC ADENOCARCINOMA: Administer the CLR-TargoSphere® encapsulated combination of gemcitabine, paclitaxel, and curcumin to the primary tumor, metastases, and tumor-draining lymph nodes for a synergistic antiproliferative.The Goal: Improve progression-free and overall survival rates in comparison to the combination of non-targeted gemcitabine and nab-paclitaxel.
In the News…
- Rodos Biotarget Receives Government Funding for Developing Antibiotic-loaded Nanocarriers - Three-year funding of EUR 2.8 million for top-tier research consortium by Germany’s BMBF. Towards advancing targeted drug application to manage treatment-resistant pathogens Hannover, Germany, 16 October 2017. In recent years, antibiotic resistances of bacterial pathogens have reached a threatening dimension…
- A Message of Thanks to All Our Backers - You have donated a grand total of $7,035, 156% of our funding goal. Your generous support has enabled the studies to begin in two weeks when we start the process of testing our hypothesis: Can Effective Targeted Delivery of Curcumin…
- Louis Capozzi Receives PRSAs Gold Anvil Award for Lifetime Achievement in Public Relations - NEW YORK (Oct. 8, 2017) — The Public Relations Society of America (PRSA) presented Louis Capozzi, APR, Fellow PRSA, with its Gold Anvil Award, the Society’s highest individual award and considered to be the Society’s lifetime achievement award. The award was presented at…
- Science Crowdfunding Campaign Exceeds Funding Goal - We are very pleased to report success in pledges of $6448 from the public at a Science Crowdfunding Platform. This is 143% of our original funding goal of $4500, permitting us to begin a preclinical Proof of Concept study in…
- Cancer Research Online Crowdsourcing Campaign Passes 78% of Funding Goal - An early-stage drug development company in South Carolina has launched an online fundraising campaign to study the ancient spice curcumin in combination with an FDA-approved Immune Checkpoint Inhibitor to fight colon cancer. Download and read the Press Release [PDF]
To develop innovative treatment options for neurodegenerative and demyelinating diseases, and cancers by targeting antiproliferative and anti-inflammatory agents to communicating cells of the immune system.